Neuroinflammation in Murine Cirrhosis is Dependent on the Gut Microbiome and is Attenuated by Fecal Transplant

Posted by: | June 28, 2019 | Comments

ABSTRACT

Neuroinflammation in Murine Cirrhosis is Dependent on the Gut Microbiome and is Attenuated by Fecal Transplant

Cirrhosis and hepatic encephalopathy (HE) is associated with an altered gut‐liver‐brain axis. Fecal microbial transplant (FMT) after antibiotics improves outcomes in HE, but the impact on brain function is unclear. The aim of this study is to determine the effect of colonization using human donors in germ‐free (GF) mice on the gut‐liver‐brain axis. GF and conventional mice were made cirrhotic using carbon tetrachloride (CCl4) and compared to controls in GF and conventional state. Additional GF mice were colonized with stool from controls (Ctrl‐Hum) and patients with cirrhosis (Cirr‐Hum). Stools from patients with HE cirrhosis after antibiotics were pooled (pre‐FMT).

Read more at: Wiley Online Library

Runping Liu, Jason D. Kang, R. Balfour Sartor, Masoumeh Sikaroodi, Andrew Fagan, Edith A. Gavis, Huiping Zhou, Phillip B. Hylemon, Jeremy W. Herzog, Xiaojiaoyang Li, Robert H. Lippman, Javier Gonzalez Maeso, James B. Wade, Siddhartha Ghosh, Emily Gurley, Patrick M. Gillevet, and Jasmohan S. Bajaj. Hepatology. https://doi.org/10.1002/hep.30827. 20 June 2019.





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