Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats

Posted by: | October 19, 2023 | Comments


Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24–5.45, p < 8.97 × 10−8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders.

Read more at: Nature

Seva G. Khambadkone, et al. Molecular Psychiatry. 18 July 2023.

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