Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

Posted by: | December 4, 2019 | Comments

Summary

Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis (MS) patients have been shown to have an altered gut microbiome. Here, we unexpectedly found that transfer of feces harvested at peak disease from the experimental autoimmune encephalomyelitis (EAE) model of MS ameliorates disease in recipients in a miRNA-dependent manner. Specifically, we show that miR-30d is enriched in the feces of peak EAE and untreated MS patients. Synthetic miR-30d given orally ameliorates EAE through expansion of regulatory T cells (Tregs). Mechanistically, miR-30d regulates the expression of a lactase in Akkermansia muciniphila, which increases Akkermansia abundance in the gut.

Read more at: Cell Host & Microbe

Shirong Liu, Rafael M. Rezende, Thais G. Moreira, Stephanie K. Tankou, Laura M. Cox, Meng Wu, Anya Song, Fyonn H. Dhang, Zhiyun Wei, Gianluca Costamagna, and Howard L. Weiner. Elsevier. DOI: https://doi.org/10.1016/j.chom.2019.10.008. 26 November 2019.





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