Potential roles of gut microbiome and metabolites in modulating ALS in mice

Posted by: | July 25, 2019 | Comments

Potential roles of gut microbiome and metabolites in modulating ALS in mice

ABSTRACT

Amyotrophic Lateral Sclerosis (ALS) is a genetically-driven neurodegenerative disorder, whose clinical manifestations may be influenced by unknown environmental factors. We demonstrate that ALS-prone SOD1-Tg mice feature a pre-symptomatic, vivarium-dependent dysbiosis and altered metabolite configuration, coupled with an exacerbated disease in germ-free or wide-spectrum antibiotic treatment conditions. We correlate 11 distinct commensals at our vivarium with mouse-ALS severity, and exemplify by their individual supplementation into antibiotic-treated SOD1-Tg mice that Akkermansia muciniphila (AM) ameliorates & Ruminococcus torques & Parabacteroides distasonis exacerbate mouse-ALS symptoms.

Read more at: Nature

Eran Blacher, et. al. Nature. DOI: 10.1038/s41586-019-1443-5. 22 Jul 2019.





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