Predominant Effect of Host Genetics on Levels of Lactobacillus johnsonii Bacteria in the Mouse Gut

Posted by: | August 7, 2019 | Comments

TRFLP patterns of fecal LAB populations obtained from C57BL/6J and BALB/c mice

ABSTRACT

The gut microbiota is strongly associated with the well-being of the host. Its composition is affected by environmental factors, such as food and maternal inoculation, while the relative impact of the host’s genetics have been recently uncovered. Here, we studied the effect of the host genetic background on the composition of intestinal bacteria in a murine model, focusing on lactic acid bacteria (LAB) as an important group that includes many probiotic strains. Based on 16S rRNA gene genotyping, variation was observed in fecal LAB populations of BALB/c and C57BL/6J mouse lines. Lactobacillus johnsonii, a potentially probiotic bacterium, appeared at significantly higher levels in C57BL/6J versus BALB/c mouse feces. In the BALB/c gut, the L. johnsonii level decreased rapidly after oral administration, suggesting that some selective force does not allow its persistence at higher levels.

Read more at: American Society for Microbiology

Keren Buhnik-Rosenblau, Yael Danin-Poleg, Yechezkel Kashi. American Society for Microbiology Journals. DOI: 10.1128/AEM.00324-11. September 8, 2011.





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