Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice

Posted by: | December 26, 2019 | Comments


Weight gain impact of 56 days of LFLS and HFHS feeding on mouse phenotype, on two groups of 11 mice that were fed either an LFLS or an HFHS diet

The intestinal microbiota and the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), have both been implicated in diet-induced obesity and dysmetabolism. These systems were recently suggested to interact during the development of obesity. We aimed at identifying the potential interactions between gut microbiota composition and the eCBome during the establishment of diet-induced obesity and metabolic complications. Male mice were fed a high-fat, high-sucrose (HFHS) diet for 56 days to assess jejunum, ileum, and cecum microbiomes by 16S rRNA gene metataxonomics as well as ileum and plasma eCBome by targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Read more at: mSystems

Sébastien Lacroix, Florent Pechereau, Nadine Leblanc, Besma Boubertakh, Alain Houde, Cyril Martin, Nicolas Flamand, Cristoforo Silvestri, Frédéric Raymond, Vincenzo Di Marzo, and Alain Veilleux. mSystems. DOI: 10.1128/mSystems.00407-19. December 2019.

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