The gut microbiome derived from anorexia nervosa patients impairs weight gain and behavioral performance in female mice

Posted by: | August 29, 2019 | Comments

ABSTRACT

The gut microbiome derived from anorexia nervosa patients impairs weight gain and behavioral performance in female mice

Anorexia nervosa (AN) results in gut dysbiosis, but whether the dysbiosis contributes to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. To address this, germ-free mice were reconstituted with the microbiota of four AN restricting-type patients (gAN mice) and four healthy control individuals (gHC mice). The effects of gut microbes on weight gain and behavioral characteristics were examined. Fecal microbial profiles in recipient gnotobiotic mice were clustered with those of the human donors. Compared with gHC mice, gAN mice showed a decrease in body weight gain, concomitant with reduced food intake. Food efficiency ratio (body weight gain/food intake) was also significantly lower in gAN mice than in gHC mice, suggesting that decreased appetite as well as the capacity to convert ingested food to unit of body substance may contribute to poor weight gain.

Read more at: Oxford Academic

Tomokazu Hata, Noriyuki Miyata, Shu Takakura, Kazufumi Yoshihara, Yasunari Asano, Tae Kimura-Todani, Makoto Yamashita, Xue-Ting Zhang, Natsuru Watanabe, Katsunaka Mikami, Yasuhiro Koga, and Nobuyuki Sudo. Endocrinology. DOI: https://doi.org/10.1210/en.2019-00408. 26 August, 2019.





Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required
Privacy Policy




Terms & Conditions | Privacy Policy | © 2019 The Translational Microbiome Research Forum