The gut microbiota influences skeletal muscle mass and function in mice

Posted by: | August 1, 2019 | Comments

ABSTRACT

The gut microbiota influences skeletal muscle mass and function in mice

The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free mice that had a gut microbiota. Compared to pathogen-free mouse skeletal muscle, germ-free mouse skeletal muscle showed atrophy, decreased expression of insulin-like growth factor 1, and reduced transcription of genes associated with skeletal muscle growth and mitochondrial function. Nuclear magnetic resonance spectrometry analysis of skeletal muscle, liver, and serum from germ-free mice revealed multiple changes in the amounts of amino acids, including glycine and alanine, compared to pathogen-free mice.

Read more at: Science Translational Medicine

Shawon Lahiri, et al. Science Translational Medicine. DOI: 10.1126/scitranslmed.aan5662. 24 July 2019.





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