The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

Posted by: | July 29, 2019 | Comments

Perturbations to the microbiota leads to enhanced viral persistence and neuro-autoimmunity

ABSTRACT

Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense following infection with a neurotropic virus through enhancing microglia function. Germfree mice or animals that receive antibiotics are unable to control viral replication within the brain leading to increased paralysis. Microglia derived from germfree or antibiotic-treated animals cannot stimulate viral-specific immunity and microglia depletion leads to worsened demyelination.

Read more at: eLife

D Garrett Brown, Raymond Soto, Soumya Yandamuri, Colleen Stone, Laura Dickey, Joao Carlos Gomes-Neto, Elissa D Pastuzyn, Rickesha Bell, Charisse Petersen, Kaitlin Buhrke, Robert S Fujinami, Ryan M O’Connell, W Zac Stephens, Jason D Shepherd, Thomas E Lane, & June L Round. eLife. DOI: 10.7554/eLife.47117. 16 Jul 2019.





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