The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

Posted by: | November 22, 2019 | Comments

Antibiotics treatment to deplete the microbiota alters the inflammatory response following lysolecithin-mediated demyelination

Significance

People with multiple sclerosis have a microbiota distinct from healthy controls, and there is growing interest in how these differences might contribute to the onset and progression of CNS autoimmunity. However, the impact that the microbiota may also have on the endogenous regeneration of myelin—remyelination—has not yet been explored. Here we show that inflammatory responses during remyelination depend upon the microbiota, being modulated by antibiotics or probiotics or in germ-free mice. In contrast, these interventions had minimal impact on the activity of oligodendrocyte progenitor cells, with only supratherapeutic doses of antibiotics having an inhibitory effect. Our results suggest that endogenous CNS remyelination is largely resilient to interventions that modify the microbiota.

Read more at: PNAS

Christopher E. McMurran, Alerie Guzman de la Fuente, Rosana Penalva, Ofra Ben Menachem-Zidon, Yvonne Dombrowski, John Falconer, Ginez A. Gonzalez, Chao Zhao, Fynn N. Krause, Adam M. H. Young, Julian L. Griffin, Clare A. Jones, Claire Hollins, Markus M. Heimesaat, Denise C. Fitzgerald, and Robin J. M. Franklin. Proceedings of the National Academy of Sciences. DOI: https://doi.org/10.1073/pnas.1905787116. 18 Nov 2019.





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