Fasting and timed feeding strategies normalize obesity parameters even under high-fat dietary intake. Although previous work demonstrated that these dietary strategies reduce adiposity and improve metabolic health, limited work has examined intestinal microbial communities.
We determined whether timed feeding modifies the composition of the intestinal microbiome and mycobiome (yeast and fungi).
Male C57BL/6 mice were fed a high-fat diet (HF) for 6 wk. Animals were then randomly assigned to the following groups (n = 8–10/group): 1) HF ad libitum; 2) purified high-fiber diet (Daniel Fast, DF); 3) HF–time-restricted feeding (TRF) (6 h); 4) HF–alternate-day fasting (ADF); or 5) HF at 80% total caloric restriction (CR). After 8 wk, obesity and gut parameters were characterized. We also examined changes to the gut microbiome and mycobiome before, during, and following dietary interventions.
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