Toll‐like receptor 2 and toll‐like receptor 4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota

Posted by: | May 30, 2019 | Comments

ABSTRACT

BACKGROUND

Toll‐like receptor 2 and toll‐like receptor 4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota

Oral gingival tissue, especially the junctional epithelium (JE), is constantly exposed to sub‐gingival plaque. A key component of gingival health is the regulation of the number of neutrophils that migrate into the gingival crevice to counteract its harmful effects. This report investigates the contribution of innate defense receptors, Toll‐like receptor 2 (TLR), TLR4 and both (TLR2/4) to the maintenance of neutrophil homeostasis in the JE.

Read more at: American Academy of Periodontology Journals

Ana M. Chang B.S., B.A., Quanhui Liu M.S., Adeline M. Hajjar D.V.M., Ph.D., Ara Greer D.D.S., Ph.D., Jeffrey S. McLean Ph.D., and Richard P. Darveau Ph.D. Journal of Periodontology. DOI: https://doi.org/10.1002/JPER.18-0719. 21 May 2019.





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