Vendor‐Specific Microbiome Controls both Acute and Chronic Murine Lung Allograft Rejection by Altering CD4+Foxp3+ Regulatory T Cell Levels

Posted by: | July 11, 2019 | Comments

ABSTRACT

Vendor‐Specific Microbiome Controls both Acute and Chronic Murine Lung Allograft Rejection by Altering CD4+Foxp3+ Regulatory T Cell Levels

Despite standardized post‐operative care some lung transplant patients suffer multiple episodes of acute and chronic rejection while others avoid graft problems for reasons that are poorly understood. Using an established model of C57BL/10 to C57BL/6 minor antigen mismatched single lung transplantation we now demonstrate that the recipient microbiota contributes to variability in the alloimmune response. Specifically, mice from the Envigo facility in Frederick Maryland contain nearly double the number of CD4+Foxp3+ regulatory T cells (Tregs) than mice from the Jackson facility in Bar Harbor Maine or the Envigo facility in Indianapolis Indiana (18 vs. 9 vs. 7%).

Read more at: Wiley Online Library

Yizhan Guo, Qing Wang, Dongge Li, Oscar Okwudiri Onyema, Zhongcheng Mei, Amir Manafi, Anirban Banerjee, Bayan Mahgoub, Mark H. Stoler, Thomas H. Barker, David S. Wilkes, Andrew E. Gelman, Daniel Kreisel, and Alexander Sasha Krupnick. American Journal of Transplantation. DOI: https://doi.org/10.1111/ajt.15523. 06 July 2019.





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