Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance

Posted by: | October 26, 2023 | Comments

•Wild mice from Maryland are close relatives to standard laboratory mouse strains
•Gut microbiota of wild mice and laboratory mice differ significantly
•Wild mouse gut microbiota can be banked and maintained in a laboratory mouse colony
•Natural gut microbiota improves outcome in viral infection and tumorigenesis models

Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living mammals. Because the microbiome is a major factor in mammalian physiology, we aimed to identify a naturally evolved reference microbiome to better recapitulate physiological phenomena relevant in the natural world outside the laboratory. Among 21 distinct mouse populations worldwide, we identified a closely related wild relative to standard laboratory mouse strains. Its bacterial gut microbiome differed significantly from its laboratory mouse counterpart and was transferred to and maintained in laboratory mice over several generations. Laboratory mice reconstituted with natural microbiota exhibited reduced inflammation and increased survival following influenza virus infection and improved resistance against mutagen/inflammation-induced colorectal tumorigenesis. By demonstrating the host fitness-promoting traits of natural microbiota, our findings should enable the discovery of protective mechanisms relevant in the natural world and improve the modeling of complex diseases of free-living mammals.

Read At: Science Direct

Stephan P. Rosshart, Brian G. Vassallo, Davide Angeletti, Diane S. Hutchinson, Andrew P. Morgan, Kazuyo Takeda5 Heather D. Hickman, John A. McCulloch, Jonathan H. Badger, Nadim J. Ajami, Giorgio Trinchieri, Fernando Pardo-Manuel de Villena, Jonathan W. Yewdell, Barbara Rehermann1. Received 9 April 2017, Revised 12 June 2017, Accepted 9 September 2017, Available online 19 October 2023 Published: October 19, 2017.

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